Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing a...
Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing and promotes production of shorter, less toxic Aβ peptides
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Background The brains of patients with Alzheimer’s disease (AD) reveal increased cellular membrane levels of cholesterol. Correspondingly, we previously showed that elevating levels of membrane cholesterol in neuronal cultures recapitulates early AD phenotypes including excessive cleavage of amyloid β (Aβ) peptides from the amyloid precurs...
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Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing and promotes production of shorter, less toxic Aβ peptides
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TN_cdi_proquest_journals_2507169750
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507169750
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2692-8205
DOI
10.1101/2020.11.16.384891
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https://www.proquest.com/docview/2507169750?pq-origsite=primo&accountid=13902
