Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived N...
Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
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Author / Creator
Pak, Changhui , Danko, Tamas , Mirabella, Vincent R , Wang, Jinzhao , Zhang, Xianglong , Ward, Thomas , Grieder, Sarah , Vangipuram, Madhuri , Yu-Wen, Alvin Huang , Liu, Yingfei , Kang, Jin , Dexheimer, Philip , Bardes, Eric , Mittelpunkt, Alexis , Ma, Junyi , Mclachlan, Michael , Moore, Jennifer C , Urban, Alexander E , Dage, Jeffrey L , Swanson, Bradley J , Aronow, Bruce J , Pang, Zhiping P , Levinson, Douglas F , Wernig, Marius and Südhof, Thomas C
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
ABSTRACT Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation predisposing to schizophrenia. Previous studies showed that engineered heterozygous NRXN1 deletions impaired neurotransmitter release in human neurons, suggesting a synaptic pathophysiological mechanism. Utilizing this observation for drug disco...
Alternative Titles
Full title
Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
Authors, Artists and Contributors
Author / Creator
Danko, Tamas
Mirabella, Vincent R
Wang, Jinzhao
Zhang, Xianglong
Ward, Thomas
Grieder, Sarah
Vangipuram, Madhuri
Yu-Wen, Alvin Huang
Liu, Yingfei
Kang, Jin
Dexheimer, Philip
Bardes, Eric
Mittelpunkt, Alexis
Ma, Junyi
Mclachlan, Michael
Moore, Jennifer C
Urban, Alexander E
Dage, Jeffrey L
Swanson, Bradley J
Aronow, Bruce J
Pang, Zhiping P
Levinson, Douglas F
Wernig, Marius
Südhof, Thomas C
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2507275363
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507275363
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.11.03.366617
How to access this item
https://www.proquest.com/docview/2507275363?pq-origsite=primo&accountid=13902
