Brain-Restricted mTOR Inhibition with Binary Pharmacology
Brain-Restricted mTOR Inhibition with Binary Pharmacology
About this item
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Abstract On-target-off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates. In diseases of the central nervous system, drugs with brain-restricted pharmacology are highly desirable. Here we report a strategy to achieve inhibition of mTOR while sparing mTOR activity elsewhere thr...
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Full title
Brain-Restricted mTOR Inhibition with Binary Pharmacology
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TN_cdi_proquest_journals_2507988193
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507988193
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E-ISSN
2692-8205
DOI
10.1101/2020.10.12.336677
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https://www.proquest.com/docview/2507988193?pq-origsite=primo&accountid=13902
