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β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508125875

β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

About this item

Full title

β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-09

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract The number and activity of Cav1.2 channels in the cardiomyocyte sarcolemma tunes the magnitude of Ca2+-induced Ca2+ release and myocardial contraction. β-adrenergic receptor (βAR) activation stimulates sarcolemmal insertion of CaV1.2 channels. This supplements the pre-existing sarcolemmal CaV1.2 population, forming large ‘super-clusters’ w...

Alternative Titles

Full title

β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2508125875

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508125875

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.09.28.317362