MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell d...
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4 enzymatic activities and MLL3/4-mediated enhancer H3K4me1 in these processes remain unclear. Here, we report that constitutive elimination of both MLL3 and MLL4 enzymatic activities leads to g...
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Full title
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
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TN_cdi_proquest_journals_2508229449
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508229449
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E-ISSN
2692-8205
DOI
10.1101/2020.09.14.296558
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https://www.proquest.com/docview/2508229449?pq-origsite=primo&accountid=13902
