Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation...
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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ABSTRACT PARP-1 is a key early responder to DNA damage in eukaryotic cells. An allosteric mechanism links initial sensing of DNA single-strand breaks by PARP-1’s F1 and F2 domains via a process of further domain assembly to activation of the catalytic domain (CAT); synthesis and attachment of poly(ADP-ribose) (PAR) chains to protein sidechains then...
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Full title
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
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TN_cdi_proquest_journals_2508494850
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508494850
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E-ISSN
2692-8205
DOI
10.1101/2020.09.04.283309
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https://www.proquest.com/docview/2508494850?pq-origsite=primo&accountid=13902
