Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-C...
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
About this item
Full title
Author / Creator
Drayman, Nir , Jones, Krysten A , Saara-Anne Azizi , Froggatt, Heather M , Tan, Kemin , Maltseva, Natalia Ivanovna , Chen, Siquan , Nicolaescu, Vlad , Dvorkin, Steve , Furlong, Kevin , Kathayat, Rahul S , Firpo, Mason R , Mastrodomenico, Vincent , Bruce, Emily A , Schmidt, Madaline M , Jedrzejczak, Robert , Muñoz-Alía, Miguel Á , Schuster, Brooke , Nair, Vishnu , Botten, Jason W , Brooke, Christopher B , Baker, Susan C , Mounce, Bryan C , Heaton, Nicholas S , Dickinson, Bryan C , Jaochimiak, Andrzej , Randall, Glenn and Tay, Savaş
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Abstract There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest path to clinical use is repurposing of drugs that have an established safety profile in humans. Here, we first screened a library of 1,900 clinically safe drugs for inhibiting replication of OC43, a human beta-coronavirus that causes the common-cold...
Alternative Titles
Full title
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
Authors, Artists and Contributors
Author / Creator
Jones, Krysten A
Saara-Anne Azizi
Froggatt, Heather M
Tan, Kemin
Maltseva, Natalia Ivanovna
Chen, Siquan
Nicolaescu, Vlad
Dvorkin, Steve
Furlong, Kevin
Kathayat, Rahul S
Firpo, Mason R
Mastrodomenico, Vincent
Bruce, Emily A
Schmidt, Madaline M
Jedrzejczak, Robert
Muñoz-Alía, Miguel Á
Schuster, Brooke
Nair, Vishnu
Botten, Jason W
Brooke, Christopher B
Baker, Susan C
Mounce, Bryan C
Heaton, Nicholas S
Dickinson, Bryan C
Jaochimiak, Andrzej
Randall, Glenn
Tay, Savaş
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2508532239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508532239
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2020.08.31.274639
