Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides
Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Steric-blocking oligonucleotides (SBOs) are short, single-stranded nucleic acids designed to modulate gene expression by binding to mRNA and blocking access from cellular machinery such as splicing factors. SBOs have the potential to bind to near-complementary sites in the transcriptome, causing off-target effects. In this study, we used R...
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Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides
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TN_cdi_proquest_journals_2508532262
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508532262
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E-ISSN
2692-8205
DOI
10.1101/2020.09.03.281667
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https://www.proquest.com/docview/2508532262?pq-origsite=primo&accountid=13902
