Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation
Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation
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Author / Creator
Mark Borris D Aldonza , Cha, Junghwa , Yong, Insung , Ku, Jayoung , Lee, Dabin , Sinitcyn, Pavel , Cho, Ryeong-Eun , Delos Reyes, Roben D , Kim, Dongwook , Hye-Jin, Sung , Kim, Soyeon , Kang, Minjeong , Ku, Yongsuk , Park, Geonho , Ryu, Han Suk , Cho, Sukki , Kim, Tae Min , Kim, Pilnam , Cho, Je-Yoel and Kim, Yoosik
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post-translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed that...
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Full title
Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation
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TN_cdi_proquest_journals_2516612007
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2516612007
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.04.21.440719
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https://www.proquest.com/docview/2516612007?pq-origsite=primo&accountid=13902
