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Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents

Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2517673802

Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents

About this item

Full title

Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents

Author / Creator

Publisher

New York: Springer US

Journal title

Investigational new drugs, 2021-06, Vol.39 (3), p.756-763

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Summary
PENAO (4-(N-(S-penicillaminylacetyl)amino)phenylarsonous acid) is a second-generation peptide arsenical that inactivates mitochondria in proliferating tumour cells by covalently reacting with mitochondrial inner-membrane adenine nucleotide transferase. The toxicokinetics of PENAO has been investigated in Sprague-Dawley rats to inform rou...

Alternative Titles

Full title

Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2517673802

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2517673802

Other Identifiers

ISSN

0167-6997

E-ISSN

1573-0646

DOI

10.1007/s10637-021-01065-x

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