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A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic...

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2518567474

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic mRNAs

About this item

Full title

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic mRNAs

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Stress-induced cleavage of transfer RNAs (tRNAs) into tRNA-derived fragments (tRFs) occurs across organisms from yeast to human, yet its mechanistic bases and pathological consequences remain poorly defined. By performing genome-wide small RNA profiling, we detected increased abundance of a Cysteine tRNA fragment (5'-tRFCys) during breast cancer me...

Alternative Titles

Full title

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic mRNAs

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2518567474

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2518567474

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.04.26.441477