Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is ass...
Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Pharmacological treatment of Duchenne Muscular Dystrophy (DMD) with histone deacetylase inhibitors (HDACi) is currently being tested in clinical trials. Pre-clinical studies performed in mdx mice - the mouse model of DMD - have shown that HDACi promote compensatory muscle regeneration, while inhibiting fibro-adipogenic degeneration, by targeting fi...
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Full title
Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence
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TN_cdi_proquest_journals_2518860195
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2518860195
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E-ISSN
2692-8205
DOI
10.1101/2021.04.26.441412
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https://www.proquest.com/docview/2518860195?pq-origsite=primo&accountid=13902
