Log in to save to my catalogue

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse...

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2520256923

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

About this item

Full title

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Mutation in the DYRK1A gene located on human chromosome 21 (Hsa21) leads to an intellectual disability syndrome associated with microcephaly, epilepsy, and autistic troubles (MRD...

Alternative Titles

Full title

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2520256923

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2520256923

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.05.01.442242