Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardi...
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
About this item
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and impedes its contractile function. Detyrosination promotes interactions between microtubules, desmin intermediate filaments and the sarcomere to increase cytoskeletal stiffness, yet the mechanism by which this occurs is unknown....
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Full title
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
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TN_cdi_proquest_journals_2533061538
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2533061538
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E-ISSN
2692-8205
DOI
10.1101/2021.05.26.445641
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https://www.proquest.com/docview/2533061538?pq-origsite=primo&accountid=13902
