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Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-ind...

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-ind...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2548028932

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

About this item

Full title

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-07

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Lineage dedifferentiation towards a mesenchymal-like state is a common mechanism of adaptive response and resistance to targeted therapy in melanoma. Yet, the transcriptional network driving this phenotypic plasticity remains elusive. Remarkably, this cellular state displays myofibroblast and fibrotic features and escapes MAPK inhibitors (MAPKi) th...

Alternative Titles

Full title

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2548028932

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2548028932

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.07.02.450838