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DNA double strand break position leads to distinct gene expression changes and regulates VSG switchi...

DNA double strand break position leads to distinct gene expression changes and regulates VSG switchi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2551804516

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

About this item

Full title

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-07

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Antigenic variation is an immune evasion strategy used by Trypanosoma brucei that results in the periodic exchange of the surface protein coat. Underlying this process is the movement of variant surface glycoprotein genes in or out of a specialized locus known as bloodstream form expression site by homologous recombination, facilitated by blocks of...

Alternative Titles

Full title

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2551804516

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2551804516

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.07.15.452463