387 A Phase II, multicenter study of the safety and efficacy of LAG525 in combination with spartaliz...
387 A Phase II, multicenter study of the safety and efficacy of LAG525 in combination with spartalizumab in patients with advanced malignancies
About this item
Full title
Author / Creator
Chia-Chi, Lin , Garralda, Elena , Schöffski, Patrick , Hong, David , Siu, Lillian , Martin, Miguel , Maur, Michela , Hui, Rina , Ross, Soo , Chiu, Joanne , Zhang, Tian , Ma, Brigette , Kyi, Chrisann , Tan, Daniel , Cassier, Philippe , Sarantopoulos, John , Weickhardt, Andrew , Carvajal, Rich , Spratlin, Jennifer , Esaki, Taito , Rolland, Fréderic , Akerley, Wallace , Deschler-Baier, Barbara , Sabatos-Peyton, Catherine , Niladri Roy Chowdhury , Gusenleitner, Daniel , Kwak, Eunice , Askoxylakis, Vasileios and De Braud, Filippo
Publisher
London: BMJ Publishing Group LTD
Journal title
Language
English
Formats
Publication information
Publisher
London: BMJ Publishing Group LTD
Subjects
More information
Scope and Contents
Contents
BackgroundExpression of LAG-3, an inhibitory immunoreceptor, has been linked to reduced T-cell proliferation and cytokine production. LAG525 is a humanized IgG4 anti-LAG-3 antibody which inhibits LAG-3 binding to MHC class II. Spartalizumab is a humanized IgG4 anti-PD-1 mAb which inhibits PD-1 binding with its ligands PD-L1 and PD-L2. Preclinical d...
Alternative Titles
Full title
387 A Phase II, multicenter study of the safety and efficacy of LAG525 in combination with spartalizumab in patients with advanced malignancies
Authors, Artists and Contributors
Author / Creator
Garralda, Elena
Schöffski, Patrick
Hong, David
Siu, Lillian
Martin, Miguel
Maur, Michela
Hui, Rina
Ross, Soo
Chiu, Joanne
Zhang, Tian
Ma, Brigette
Kyi, Chrisann
Tan, Daniel
Cassier, Philippe
Sarantopoulos, John
Weickhardt, Andrew
Carvajal, Rich
Spratlin, Jennifer
Esaki, Taito
Rolland, Fréderic
Akerley, Wallace
Deschler-Baier, Barbara
Sabatos-Peyton, Catherine
Niladri Roy Chowdhury
Gusenleitner, Daniel
Kwak, Eunice
Askoxylakis, Vasileios
De Braud, Filippo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2553007253
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2553007253
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-SITC2020.0387
