Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of...
Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities, however, the high molecular weight limits their bioavailability for otherwise treatable neurological disorders. We investigated conjugation of ASOs to an antibody against the murine transferrin receptor (TfR), 8D3130, and evaluated it via syste...
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Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy
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TN_cdi_proquest_journals_2556161037
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2556161037
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E-ISSN
2692-8205
DOI
10.1101/2021.07.29.454272
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https://www.proquest.com/docview/2556161037?pq-origsite=primo&accountid=13902
