Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
About this item
Full title
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Nature structural & molecular biology, 2020-06, Vol.27 (6), p.533-539
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The Na
+
/I
−
symporter (NIS), the plasma membrane protein that actively transports I
−
(stoichiometry 2Na
+
:1I
−
) in thyroid physiology and radioiodide-based thyroid cancer treatment, also transports the environmental pollutant perchlorate (stoichiometry 1Na
+
:1ClO
4
−
), which competes with I
−
Alternative Titles
Full title
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2556548963
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2556548963
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-0417-5
