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Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity...

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2559762905

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

About this item

Full title

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Publisher

New York: Nature Publishing Group

Journal title

Nature genetics, 2021-08, Vol.53 (8), p.1221-5

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group

More information

Scope and Contents

Contents

Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we use human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landsc...

Alternative Titles

Full title

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2559762905

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2559762905

Other Identifiers

ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.38/s41588-021-00897-w

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