A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins
A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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ABSTRACT Deep mutational scanning is a powerful method to explore the mutational fitness landscape of proteins. Its adaptation to anti-CRISPR proteins, which are natural CRISPR-Cas inhibitors and key players in the co-evolution of microbes and phages, would facilitate their in-depth characterization and optimization. Here, we developed a robust ant...
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Full title
A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins
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TN_cdi_proquest_journals_2564142669
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2564142669
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E-ISSN
2692-8205
DOI
10.1101/2021.08.21.457204
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https://www.proquest.com/docview/2564142669?pq-origsite=primo&accountid=13902
