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Sequence grammar underlying unfolding and phase separation of globular proteins

Sequence grammar underlying unfolding and phase separation of globular proteins

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2564148103

Sequence grammar underlying unfolding and phase separation of globular proteins

About this item

Full title

Sequence grammar underlying unfolding and phase separation of globular proteins

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Aberrant phase separation of globular proteins is associated with many diseases. Here, we use a model protein system to understand how unfolded states of globular proteins drive phase separation and the formation of unfolded protein deposits (UPODs). For UPODs to form, the concentrations of unfolded molecules must be above a threshold value. Additi...

Alternative Titles

Full title

Sequence grammar underlying unfolding and phase separation of globular proteins

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2564148103

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2564148103

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.08.20.457073