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A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contracep...

A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contracep...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2577919313

A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors

About this item

Full title

A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Cancer chemotherapy and pharmacology, 2021-11, Vol.88 (5), p.887-897

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Purpose
This study aimed at evaluating the effect of rucaparib on the pharmacokinetics of rosuvastatin and oral contraceptives in patients with advanced solid tumors and the safety of rucaparib with and without coadministration of rosuvastatin or oral contraceptives.
Methods
Patients received single doses of oral rosuvastatin 20 mg (Arm A)...

Alternative Titles

Full title

A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2577919313

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2577919313

Other Identifiers

ISSN

0344-5704

E-ISSN

1432-0843

DOI

10.1007/s00280-021-04338-7

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