Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induc...
Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells
About this item
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Author / Creator
Fan, Yongna , Xie, Ping , Zhang, Hua , Guo, Shubin , Gu, Dongfeng , She, Mingpeng and Li, HuiHua
Publisher
Boston: Boston : Springer US
Journal title
Language
English
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Publication information
Publisher
Boston: Boston : Springer US
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Scope and Contents
Contents
Apoptosis of vascular smooth muscle cells (SMCs) is a prominent feature of blood vessel remodeling. Here we investigated the effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) on SMC apoptosis. We found that TPA treatment induced SMC apoptosis through the rapid downregulation of Akt phosphorylation. The inhibition of Akt activation by TPA was mar...
Alternative Titles
Full title
Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells
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Author / Creator
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Record Identifier
TN_cdi_proquest_journals_2603343813
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2603343813
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ISSN
1360-8185
E-ISSN
1573-675X
DOI
10.1007/s10495-008-0272-z
