Guiding ATR and PARP inhibitor combinations with chemogenomic screens
Guiding ATR and PARP inhibitor combinations with chemogenomic screens
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Combinations of inhibitors of Ataxia Telangiectasia- and Rad3-related kinase (ATRi) and poly(ADP-ribose) polymerases (PARPi) synergistically kill tumor cells through modulation of complementary DNA repair pathways, but their tolerability is limited by hematological toxicities. To address this we performed a genome-wide CRISPR/Cas9 screen to identif...
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Full title
Guiding ATR and PARP inhibitor combinations with chemogenomic screens
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TN_cdi_proquest_journals_2609869276
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2609869276
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E-ISSN
2692-8205
DOI
10.1101/2021.12.13.472393
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https://www.proquest.com/docview/2609869276?pq-origsite=primo&accountid=13902
