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Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive gro...

Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive gro...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2610236127

Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice

About this item

Full title

Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice

Publisher

England: Nature Publishing Group

Journal title

Neuropsychopharmacology (New York, N.Y.), 2022-01, Vol.47 (2), p.477-487

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

More information

Scope and Contents

Contents

Excessive grooming of Sapap3-KO mice has been used as a model of obsessive-compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal circuits is critically important in the generation of compulsive behaviors, and it has been proposed that the alteration in the activity patterns of striatal circuitry underlies the ex...

Alternative Titles

Full title

Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2610236127

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2610236127

Other Identifiers

ISSN

0893-133X,1740-634X

E-ISSN

1740-634X

DOI

10.1038/s41386-021-01161-9

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