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Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2612229334

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Tumor myeloid suppressor cells impede response to T cell checkpoint immunotherapy. Immunoglobulin-like transcript 3 (ILT3, gene name, LILRB4) expressed on dendritic cells (DCs) promotes antigen-specific tolerance. Circulating monocytic MDSCs that express ILT3 have been linked to clinical outcomes and a soluble form of ILT3 is elevated in certain ca...

Alternative Titles

Full title

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2612229334

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2612229334

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.12.18.472552