Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia
Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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We previously found that T-cell acute lymphoblastic leukemia (T-ALL) requires support from tumor-associated myeloid cells, which activate IGF1R signaling in the leukemic blasts. However, IGF1 is not sufficient to sustain T-ALL survival in vitro, implicating additional myeloid-mediated signals in T-ALL progression. Here, we find that T-ALL cells req...
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Full title
Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia
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TN_cdi_proquest_journals_2616787013
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2616787013
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E-ISSN
2692-8205
DOI
10.1101/2022.01.05.475106
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https://www.proquest.com/docview/2616787013?pq-origsite=primo&accountid=13902
