Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
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Author / Creator
Baidya, Mithu , Chaturvedi, Madhu , Dwivedi-Agnihotri, Hemlata , Ranjan, Ashutosh , Devost, Dominic , Yoon Namkung , Stepniewski, Tomasz Maciej , Pandey, Shubhi , Baruah, Minakshi , Panigrahi, Bhanupriya , Maharana, Jagannath , Banerjee, Ramanuj , Selent, Jana , Laporte, Stephane , Hebert, Terence E and Shukla, Arun K
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a primary determinant of β-arrestin (βarr) recruitment and trafficking. For several GPCRs, such as the vasopressin type II receptor (V2R), which exhibit high affinity for βarrs, agonist-stimulation first drives the translocation of βarrs to the plasma membrane, followed by en...
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Full title
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
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TN_cdi_proquest_journals_2618752506
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2618752506
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E-ISSN
2692-8205
DOI
10.1101/2022.01.11.475811
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https://www.proquest.com/docview/2618752506?pq-origsite=primo&accountid=13902
