Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mi...
Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy
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Särchen, Vinzenz , Shanmugalingam, Senthan , Kehr, Sarah , Reindl, Lisa Marie , Greze, Victoria , Wiedemann, Sara , Boedicker, Cathinka , Jacob, Maureen , Bankov, Katrin , Becker, Nina , Wehner, Sibylle , Theilen, Till M. , Gretser, Steffen , Gradhand, Elise , Kummerow, Carsten , Ullrich, Evelyn and Vogler, Meike
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of pro- and antiapoptotic Bcl-2 proteins. BH3 mimetics neutralize the antiapoptotic function of Bcl-2 proteins and are highly promising compounds inducing apoptosis in several cancer entities including pedia...
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Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy
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TN_cdi_proquest_journals_2619581405
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2619581405
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ISSN
2058-7716
E-ISSN
2058-7716
DOI
10.1038/s41420-021-00812-6
