Log in to save to my catalogue

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltrans...

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltrans...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2627874871

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

About this item

Full title

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Changes in bacterial ribosomal RNA methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on one nucleotide target and rRNA methylation directly prevents drug binding, thereby conferring drug resistance. Loss of intrinsic m...

Alternative Titles

Full title

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2627874871

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2627874871

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.11.11.467980