Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
About this item
Full title
Author / Creator
Challoner, Benjamin Robert , Woolston, Andrew , Lau, David , Buzzetti, Marta , Fong, Caroline , Barber, Louise J , Anandappa, Gayathri , Crux, Richard , Assiotis, Ioannis , Fenwick, Kerry , Begum, Ruwaida , Begum, Dipa , Lund, Tom , Sivamanoharan, Nanna , Sansano, Harold B , Domingo-Arada, Melissa , Tran, Amina , Eccles, Bryony , Ellis, Richard , Falk, Stephen , Hill, Mark , Krell, Daniel , Murugaesu, Nirupa , Nolan, Luke , Potter, Vanessa , Saunders, Mark , Kai-Keen Shiu , Guettler, Sebastian , Alexander, James L , Lázare-Iglesias, Héctor , Kinross, James , Murphy, Jamie , Katharina Von Loga , Cunningham, David , Chau, Ian , Starling, Naureen , Ruiz-Bañobre, Juan , Dhillon, Tony and Gerlinger, Marco
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Mismatch repair deficient colorectal cancers have high mutation loads and many respond to immune checkpoint-inhibitors. We investigated how genetic and immune landscapes co-evolve in these tumors. All cases had high truncal mutation loads. Driver aberrations showed a clear hierarchy despite pervasive intratumor heterogeneity: Those in WNT/βCatenin,...
Alternative Titles
Full title
Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
Authors, Artists and Contributors
Author / Creator
Woolston, Andrew
Lau, David
Buzzetti, Marta
Fong, Caroline
Barber, Louise J
Anandappa, Gayathri
Crux, Richard
Assiotis, Ioannis
Fenwick, Kerry
Begum, Ruwaida
Begum, Dipa
Lund, Tom
Sivamanoharan, Nanna
Sansano, Harold B
Domingo-Arada, Melissa
Tran, Amina
Eccles, Bryony
Ellis, Richard
Falk, Stephen
Hill, Mark
Krell, Daniel
Murugaesu, Nirupa
Nolan, Luke
Potter, Vanessa
Saunders, Mark
Kai-Keen Shiu
Guettler, Sebastian
Alexander, James L
Lázare-Iglesias, Héctor
Kinross, James
Murphy, Jamie
Katharina Von Loga
Cunningham, David
Chau, Ian
Starling, Naureen
Ruiz-Bañobre, Juan
Dhillon, Tony
Gerlinger, Marco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2630554367
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2630554367
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.02.16.479224
How to access this item
https://www.proquest.com/docview/2630554367?pq-origsite=primo&accountid=13902
