Early identification of cooperative fragments for protein-protein interaction stabilization
Early identification of cooperative fragments for protein-protein interaction stabilization
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Modulating protein-protein interactions (PPIs) is an effective approach to drug discovery, with several drugs in the clinic that inhibit PPIs. The orthogonal approach of PPI stabilization has developed slowly, a function of the complicated dynamics of multi-component protein complexes. In contrast to PPI inhibition, where ligand affinity is the dri...
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Full title
Early identification of cooperative fragments for protein-protein interaction stabilization
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TN_cdi_proquest_journals_2632512513
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2632512513
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E-ISSN
2692-8205
DOI
10.1101/2022.02.23.481635
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https://www.proquest.com/docview/2632512513?pq-origsite=primo&accountid=13902
