Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG
Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG
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Author / Creator
Mbah, Nneka , Myers, Amy , Chan, Chung , Thompson, Joyce , Hong, Hanna , Sajjakulnukit, Peter , Nwosu, Zeribe , Mengrou Shan , Sweha, Stefan , Maydan, Daniella , Chen, Brandon , Zhang, Li , Magnuson, Brian , Zirui Zui , Wahl, Daniel , Franchi, Luigi , Agnihotri, Sameer , Koschmann, Carl , Venneti, Sriram and Lyssiotis, Costas A
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
H3K27M diffuse intrinsic pontine gliomas (DIPG) exhibit cellular heterogeneity comprising less-differentiated, stem-like glioma cells that resemble oligodendrocyte precursors (OPC) and more differentiated astrocyte (AC)-like cells. H3K27M DIPG stem-like cells exhibit tumor-seeding capabilities in vivo, a feature lost or greatly diminished in the mo...
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Full title
Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG
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TN_cdi_proquest_journals_2635342932
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2635342932
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E-ISSN
2692-8205
DOI
10.1101/2022.03.01.482555
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https://www.proquest.com/docview/2635342932?pq-origsite=primo&accountid=13902
