Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
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Author / Creator
Mumford, Paige , Tosh, Justin , Anderle, Silvia , Wikberg, Eleni Gkanatsiou , Lau, Gloria , Noy, Sue , Cleverley, Karen , Saito, Takashi , Saido, Takaomi C , Yu, Eugene Y , Brinkmalm, Gunnar , Portelius, Erik , Blennow, Kaj , Zetterberg, Henrik , Tybulewicz, Victor , Fisher, Elizabeth and Wiseman, Frances K
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
People who have Down syndrome have three copies of chromosome 21 and thus also an additional copy of APP; this genetic change drives the early development of Alzheimers disease in these individuals. Here we use a combination of next-generation mouse models of Down syndrome (Tc1, Dp3Tyb, Dp(10)2Yey and Dp(17)3Yey) and a knockin mouse model of amyloi...
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Full title
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
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Record Identifier
TN_cdi_proquest_journals_2638313300
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2638313300
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.03.10.483782
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https://www.proquest.com/docview/2638313300?pq-origsite=primo&accountid=13902
