Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and g...
Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Nucleosomes drastically limit transcription factor (TF) occupancy, while pioneer transcription factors (PFs) somehow circumvent this nucleosome barrier. In this study, we compare nucleosome binding of two conserved S. cerevisiae basic helix-loop-helix (bHLH) TFs, Cbf1 and Pho4. A Cryo-EM structure of Cbf1 in complex with the nucleosome reveals that...
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Full title
Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions
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TN_cdi_proquest_journals_2640466895
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2640466895
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E-ISSN
2692-8205
DOI
10.1101/2022.03.17.484790
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https://www.proquest.com/docview/2640466895?pq-origsite=primo&accountid=13902
