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Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives eryth...

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives eryth...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2641679374

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

About this item

Full title

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-03

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. We discovered that SLC7A1/CAT1-dependent arginine uptake and its catabolism to spermidine control the erythroid specification of HSPCs via activation of eukaryot...

Alternative Titles

Full title

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2641679374

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2641679374

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.03.21.485053