Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral bl...
Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor κB
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Author / Creator
Nishioka, C , Ikezoe, T , Togitani, K and Yokoyama, A
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Fludarabine is a purine analog that has demonstrated significant activity in B-cell malignancies, including CLL. Fludarabine also possesses an immunosuppressive effect and is being used to prevent GVHD in hematopoietic stem cell transplantation. However, the molecular mechanism by which fludarabine inhibits immunoreaction remains to be fully elucid...
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Full title
Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor κB
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TN_cdi_proquest_journals_2642232383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2642232383
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ISSN
0268-3369
E-ISSN
1476-5365
DOI
10.1038/sj.bmt.1705901
