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A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2645320483

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

About this item

Full title

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-03

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Most invasive lobular breast cancers (ILC) are of the luminal A subtype and strongly hormone receptor positive. Yet, they are relatively resistant to tamoxifen and are associated with inferior long-term outcomes compared to invasive ductal cancers (IDC). In this study, we sought to gain mechanistic insights into these clinical findings that are not...

Alternative Titles

Full title

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2645320483

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2645320483

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.03.29.486217