Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infan...
Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements
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Lanciotti, M , Dufour, C , Corral, L , Di Michele, P , Pigullo, S , De Rossi, G , Basso, G , Leszl, A , Luciani, M , Lo Nigro, L , Micalizzi, C , Valsecchi, M G , Biondi, A and Haupt, R
Publisher
London: Nature Publishing
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Language
English
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Publisher
London: Nature Publishing
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Contents
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a detoxification enzyme that protects cells against oxidative stress and toxic quinones. A polymorphism (C609T) in the gene produces in the heterozygous individuals (C/T) a reduction and in those homozygous for the variant allele (T/T) the abolishment of NQO1 protein activity. To assess whether NQO1 inacti...
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Full title
Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements
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TN_cdi_proquest_journals_2645707709
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2645707709
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/sj.leu.2403613
