Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by...
Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration
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Author / Creator
McOmish, C E , Burrows, E , Howard, M , Scarr, E , Kim, D , Shin, H-S , Dean, B , van den Buuse, M and Hannan, A J
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Phospholipase C-
β
1 (PLC-
β
1) is a rate-limiting enzyme implicated in postnatal-cortical development and neuronal plasticity. PLC-
β
1 transduces intracellular signals from specific muscarinic, glutamate and serotonin receptors, all of which have been implicated in the pathogenesis of schizophrenia. Here, we present data to show...
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Full title
Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration
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TN_cdi_proquest_journals_2645766530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2645766530
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/sj.mp.4002046
