Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria...
Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite Plasmodium falciparum
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial drug targets. Using an in-silico screen to dock thousands of small molecules into the crystal structure...
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Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite Plasmodium falciparum
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TN_cdi_proquest_journals_2647467557
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2647467557
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E-ISSN
2692-8205
DOI
10.1101/2022.04.05.487101
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https://www.proquest.com/docview/2647467557?pq-origsite=primo&accountid=13902
