Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca sign...
Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Recurrent missense mutations of the PIK3CA oncogene are among the most frequent drivers of human cancers. These often lead to constitutive activation of its product p110α, a phosphatidylinositol 3-kinase (PI3K) catalytic subunit. In addition to causing a range of rare and common cancers, the H1047R mutation is also found in affected tissues of a di...
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Full title
Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling
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TN_cdi_proquest_journals_2647467562
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2647467562
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E-ISSN
2692-8205
DOI
10.1101/2022.04.05.487130
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https://www.proquest.com/docview/2647467562?pq-origsite=primo&accountid=13902
