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Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochond...

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochond...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2652731133

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

About this item

Full title

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-04

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The synthetic glucocorticoid dexamethasone is commonly used to treat inner ear disorders. Previous work in larval zebrafish has shown that dexamethasone treatment enhances hair cell regeneration, yet dexamethasone has also been shown to inhibit regeneration of peripheral nerves after lesion. We therefore used the zebrafish model to determine the im...

Alternative Titles

Full title

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2652731133

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2652731133

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.04.19.488823