SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid
SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The SARS-CoV-2 spike protein contains a fatty acid binding site, also found in some other coronaviruses (e.g. SARS-CoV), which binds linoleic acid and is functionally important. When occupied by linoleic acid, it reduces infectivity, by "locking" the spike in a less infectious conformation. Here, we use dynamical-nonequilibrium molecular dynamics (...
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Full title
SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid
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TN_cdi_proquest_journals_2653417802
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2653417802
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E-ISSN
2692-8205
DOI
10.1101/2022.04.21.489022
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https://www.proquest.com/docview/2653417802?pq-origsite=primo&accountid=13902
