Log in to save to my catalogue

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proli...

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proli...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2656977390

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

About this item

Full title

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Publisher

London: Nature Publishing Group UK

Journal title

Oncogene, 2022-04, Vol.41 (18), p.2571-2586

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic
BRAF
V600E mutation. However, the main issue with targeted therapy is the acquisition of tumor cell resistance. In a majority of resistant melanoma cells, the resistant process consists in epithel...

Alternative Titles

Full title

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2656977390

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2656977390

Other Identifiers

ISSN

0950-9232,1476-5594

E-ISSN

1476-5594

DOI

10.1038/s41388-022-02266-1

How to access this item