T Cell-to-Stroma Enrichment (TSE) score: a gene expression metric that predicts response to immune c...
T Cell-to-Stroma Enrichment (TSE) score: a gene expression metric that predicts response to immune checkpoint inhibitors in patients with urothelial cancer
About this item
Full title
Author / Creator
Rijnders, Maud M , Nakauma-Gonzalez, J Alberto , Robbrecht, Debbie Gj , Gil-Jimenez, Alberto , Aarts, Maureen Jb , Boormans, Joost L , Hamberg, Paul , Michiel S Van Der Heijden , Szabados, Bernadett E , Geert Jlh Van Leenders , Mehra, Niven , Voortman, Jens , Westgeest, Hans M , De Wit, Ronald , Astrid Am Van Der Veldt , Reno Debets and Lolkema, Martijn P
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Immune checkpoint inhibitors (ICIs) improve overall survival in patients with metastatic urothelial cancer (mUC). To identify predictive markers of response, whole-genome DNA (n=70) and RNA-sequencing (n=41) were performed using fresh metastatic biopsies prior to treatment with pembrolizumab. PD-L1 combined positivity score failed, while tumor muta...
Alternative Titles
Full title
T Cell-to-Stroma Enrichment (TSE) score: a gene expression metric that predicts response to immune checkpoint inhibitors in patients with urothelial cancer
Authors, Artists and Contributors
Author / Creator
Nakauma-Gonzalez, J Alberto
Robbrecht, Debbie Gj
Gil-Jimenez, Alberto
Aarts, Maureen Jb
Boormans, Joost L
Hamberg, Paul
Michiel S Van Der Heijden
Szabados, Bernadett E
Geert Jlh Van Leenders
Mehra, Niven
Voortman, Jens
Westgeest, Hans M
De Wit, Ronald
Astrid Am Van Der Veldt
Reno Debets
Lolkema, Martijn P
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2671806007
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2671806007
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.05.30.493997
How to access this item
https://www.proquest.com/docview/2671806007?pq-origsite=primo&accountid=13902
