Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell...
Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Background: Glioblastoma is characterized by hyperactivation of kinase signaling pathways. Regardless, most glioblastoma clinical trials targeting kinase signaling have failed. We hypothesized that overcoming the glioblastoma kinase inhibitor tolerance requires efficient shut-down of phosphorylation-dependent signaling rewiring by simultaneous inhi...
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Full title
Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models
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TN_cdi_proquest_journals_2671806322
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2671806322
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E-ISSN
2692-8205
DOI
10.1101/2022.05.31.494146
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https://www.proquest.com/docview/2671806322?pq-origsite=primo&accountid=13902
