SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma
SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes establish and maintain chromatin accessibility and gene expression, and are frequently perturbed in cancer. Clear cell meningioma (CCM), an aggressive tumor of the central nervous system, is uniformly driven by loss of SMARCE1, an integral subunit of the mSWI/SNF core. Here,...
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SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma
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TN_cdi_proquest_journals_2678110608
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2678110608
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01077-0
