Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-m...
Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Downregulation of HLA is one of the most common tumor escape mechanisms by enabling tumors to persist in the presence of tumor-reactive T cells. HLA loss is particularly common in children with high-risk neuroblastoma, who have a 50% long-term survival despite dose-intensive regimens. We have now developed an approach for the targeted induction of...
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Full title
Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
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TN_cdi_proquest_journals_2680446678
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2680446678
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E-ISSN
2692-8205
DOI
10.1101/2022.06.21.496901
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https://www.proquest.com/docview/2680446678?pq-origsite=primo&accountid=13902
